glossary
glossary
methods for identifying and cataloguing the proteome. Proteomics approaches to studying protein function on a single protein-by-protein basis.
a protein identified as a receptor for a small molecule therapeutic or biopharmaceutical due to its perceived involvement in a disease process.
analysis of the functional activity of a set of proteins on a large scale requiring either native or recombinantly produced protein.
technical methodology for rapid analysis of proteins and their function. Proteomics tools run in a highly parallel and/or rapid way to generate data in a high throughput manner.
all the proteins encoded by the genes in an organism (the genome) and including those proteins modified after expression.
the qualitative and quantitative comparison of a proteome or proteomes under different conditions to further unravel biological processes.
a spatially defined and separated collection of individual proteins immobilised on a solid surface. A next-generation proteomics tool.
a collection of biologically active proteins in array format that demonstrate appropriate native function after immobilisation. A protein function array preserves binding properties, enzymatic function and other activities of the proteins arrayed.
polypeptides encoded by engineered DNA sequences fused to the DNA encoding a recombinant protein. Protein affinity tags remain conjugated to recombinant proteins and function as ligands for capture molecules and mediate the immobilisation of the complex.
proteins that contain inherited or chance changes in the wild type amino acid sequence arising due to single nucleotide polymorphisms (SNPs) or multiple nucleotide alterations.
a high throughput, usually semi-automated assay performed in multi-well containers with supernatants from clones of cells, also in multi-well plates.
structure activity relationship usually refers to the effects that small changes in chemical structure of a small molecule organic compound have on the biological activity of the compound.