Using Sense Proteomic arrays over 1,000 proteins can be screened from a single serum sample in a single experiment. Our content has been chosen based both on previously seen immunogenic responses (such as those reported in the SEREX database developed at the Ludwig Institute of Cancer Research) and protein families that have a known association with the disease being investigated.

Only small (~30ul) serum volumes are required per array. Importantly this minute amount of sample allows many arrays to be run from a typical 1ml serum aliquot, meaning that, for example, there is minimal use when assaying precious samples from sample banks. By including each protein in quadruplicate, we further reduce sample required, array cost and time to assay a sample.

The technique is also very fast. Tens of samples can be run by a single technician in a day. Sense Proteomic has developed sophisticated data analysis techniques to find meaning in this sea of data.

A schematic of our approach is shown below: